Nitric Oxide Bioavailability and Its Potential Relevance to the Variation in Susceptibility to the Renal and Vascular Complications in Patients With Type 2 Diabetes

OBJECTIVE—We compared the renal and systemic vascular (renovascular) response to a reduction of bioavailable nitric oxide (NO) in type 2 diabetic patients without nephropathy and of African and Caucasian heritage. RESEARCH DESIGN AND METHODS—Under euglycemic conditions, renal blood flow was determined by a constant infusion of paraminohippurate and changes in blood pressure and renal vascular resistance estimated before and after an infusion of l-Ng-monomethyl-l-arginine. RESULTS—In the African-heritage group, there was a significant fall in renal blood flow (Δ−46.0 ml/min per 1.73 m(2); P < 0.05) and rise in systolic blood pressure (Δ10.0 mmHg [95% CI 2.3–17.9]; P = 0.017), which correlated with an increase in renal vascular resistance (r(2) = 0.77; P = 0.004). CONCLUSIONS—The renal vasoconstrictive response associated with NO synthase inhibition in this study may be of relevance to the observed vulnerability to renal injury in patients of African heritage

Relationship between qualitative physics and fuzzy logic in natural subsystems

44-49The purpose of this research is to present a comparison between the two ad hoc appearance and control techniques of conceptual systems. In that respect, it is a description of the interconnected notion between the principle of qualitative physics and of ambiguous quality. On that basis the first point is to determine the key feature of each approach is significant. In the early stages of the product development and forecasting process, a large number of input energies were used for its creation. However, they are still being used in nature, though not subjectively impure. Therefore, this research presents the concept of the relationship between qualitative physics and fuzzy logic in terms of developing predictive outputs and using logical resources. Finally, the relationship between qualitative physics and fuzzy logic processes has been proven with the support of the selected natural subsystem

Development of Image Based Model for Basic Standing Yoga Poses that Control Type-2 Diabetes

Yoga is one of the ancient practices originated in India that helps in balancing mind and body of human. For the past few decades it has got wide spread throughout the world. Many are practicing it in the presence of yoga tutor or following some online modes. But improper practice may cause major harm to muscles and ligaments of the human body. There are different asanas proposed in the Patanjali Yoga Sutra that can cure different diseases. This paper, proposes a mathematical model for a set of yoga asanas that can help cure Type -2 Diabetes. A noninvasive analysis has been implemented using Kinect Sensor and LabVIEW software to analyze the performance of the practitioner. The joints are subjected to the flexibility of the practitioner without any overstress

Relationship between qualitative physics and fuzzy logic in natural subsystems

The purpose of this research is to present a comparison between the two ad hoc appearance and control techniques of conceptual systems. In that respect, it is a description of the interconnected notion between the principle of qualitative physics and of ambiguous quality. On that basis the first point is to determine the key feature of each approach is significant. In the early stages of the product development and forecasting process, a large number of input energies were used for its creation. However, they are still being used in nature, though not subjectively impure. Therefore, this research presents the concept of the relationship between qualitative physics and fuzzy logic in terms of developing predictive outputs and using logical resources. Finally, the relationship between qualitative physics and fuzzy logic processes has been proven with the support of the selected natural subsystem

IN VITRO EVALUATION OF CYTOTOXIC AND GENOTOXIC EFFECTS OF PLANT EXTRACTS FROM NOTHAPODYTES FOETIDA (WIGHT) SLEUMER (FAMILY: ICACINACEAE)

Objective: The objective of this study is to investigate cytotoxic and genotoxic properties of aqueous and methanolic extracts of the aerial parts of Nothapodytes foetida (Wight) Sleumer plant.Methods: The cytotoxic effects of aqueous and methanol extract of leaves and stem bark on cell viability of HeLa, MCF7, and HCT-15 cell lines was determined by 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazoliumbromide assay. We also confirmed the genotoxic effects of plant extracts through DNA fragmentation in cancer cells and expression pattern of apoptotic genes including p53 and caspase-3 analyzed by semiquantitative reverse transcription-polymerase chain reaction and western blotting techniques.Results: The present study revealed that, when plant extract was tested for cytotoxic activity, the data obtained from cell viability results of HeLa and MCF7 cells revealed that methanol extract of leaves and stem bark exhibited a range of significant cytotoxic activities in a dose-dependent manner varying from 2.5 to 25 μg/mL, whereas an aqueous extract of leaves and stem bark showed decreased cell viability with an increase in the concentration of both the extracts from 5 to 50 μg/mL.Conclusion: These results indicated that the crude extract aerial parts of N. foetida plant contain promising substances having a potential as cytotoxic agent

A REVIEW ON MATRIX ASSISTED LASER DESORPTION/INOZATION MASS SPECTROSCOPY

ABSTRACTMatrix assisted laser desorption ionization mass spectroscopy (MALDI-MS) is the most important technique of MS to analyze polymer systems. It isa special case of MS using specific sample preparation methods and low fluence laser desorption to create the analyte ions. This technique is basedupon an ultraviolet absorbing matrix. The matrix and the polymer are mixed at a molecular level in an appropriate solvent. The solvent helps preventaggregation of the polymer. The sample matrix mixture is placed on the sample probe tip, under vacuum conditions; the solvent is removed, leaving cocrystallizedpolymer molecules homogenously dispersed within matrix molecules. When the pulsed laser beam is tuned to the appropriate frequency,the energy is transferred to the matrix which is partially vaporized, carrying intact polymer into the vapor phase and charging the polymer chains inthe linear time of flight (TOF) analyzer. This review includes the detailed information of MALDI-MS, MALDI-TOF.Keywords: Matrix assisted laser desorption ionization mass spectroscopy, Principle, Sample preparation techniques, Matrix assisted laser desorptionionization - time of flight, Matrix assisted laser desorption ionization - mass spectrometric imaging, Applications

EFFECT OF VARIABLE CANT ANGLE ON SWEEPBACK WING

Winglets are commonly used drag-reduction and fuel-saving technologies in today’s aviation. The primary purpose of the winglets is to reduce the lift-induced drag, therefore improving fuel efficiency and aircraft performance. Traditional winglets are designed as fixed devices attached at the tips of the wings. However, because they are fixed surfaces, they give their best lift-induced drag reduction at a single design point. In this work, we propose the use of variable cant angle winglets which could potentially allow aircraft to get the best all-around performance (in terms of lift-induced drag reduction), at different angle-of-attack values. This paper describes a XFLR 3-dimensional winglets analysis that was performed on a wing of NACA2412 cross sectional airfoil. The wing has span 2.40 m, root chord 0.180 m, tip chord 0.110 m, sweep angle 5 degree and taper ratio 0.556 and for a winglet NACA 0024 cross-sectional airfoil was considered of max thickness 24 percent at 30 percent chord, max camber 0 percent at 0 percent chord. The present study shows effects of wing without winglet, wing with winglet at cant angle 30, 60, 90. The results obtained from the analysis demonstrate that by carefully adjusting the cant angle, the aerodynamic performance can be improved

An NGO-Implemented Community-Clinic Health Worker Approach to Providing Long-Term Care for Hypertension in a Remote Region of Southern India.

Poor blood pressure control results in tremendous morbidity and mortality in India where the leading cause of death among adults is from coronary heart disease. Despite having little formal education, community health workers (CHWs) are integral to successful public health interventions in India and other low- and middle-income countries that have a shortage of trained health professionals. Training CHWs to screen for and manage chronic hypertension, with support from trained clinicians, offers an excellent opportunity for effecting systemwide change in hypertension-related burden of disease. In this article, we describe the development of a program that trained CHWs between 2014 and 2015 in the tribal region of the Sittilingi Valley in southern India, to identify hypertensive patients in the community, refer them for diagnosis and initial management in a physician-staffed clinic, and provide them with sustained lifestyle interventions and medications over multiple visits. We found that after 2 years, the CHWs had screened 7,176 people over age 18 for hypertension, 1,184 (16.5%) of whom were screened as hypertensive. Of the 1,184 patients screened as hypertensive, 898 (75.8%) had achieved blood pressure control, defined as a systolic blood pressure less than 140 and a diastolic blood pressure less than 90 sustained over 3 consecutive visits. While all of the 24 trained CHWs reported confidence in checking blood pressure with a manual blood pressure cuff, 4 of the 24 CHWs reported occasional difficulty documenting blood pressure values because they were unable to write numbers properly. They compensated by asking other CHWs or members of their community to help with documentation. Our experience and findings suggest that a CHW blood pressure screening system linked to a central clinic can be a promising avenue for improving hypertension control rates in low- and middle-income countries

A hybrid content based image retrieval system using log-gabor filter banks

In this paper, a new efficient image retrieval system using sequential process of three stages with filtering technique for the feature selection is proposed. In the first stage the color features are extracted using color histogram method and in the second stage the texture features are obtained using log-Gabor filters and in the third stage shape features are extracted using shape descriptors using polygonal fitting algorithm. The proposed log-Gabor filter in the second stage has advantages of retrieving images over regular Gabor filter for texture. It provides better representation of the images. Experimental evaluation of the proposed system shows improved performance in retrieval as compared to other existing systems in terms of average precision and average recall

A Support framework To Enable the Nodes to Adapt Their Routing Strategies

An opportunistic routing algorithm adopts no awareness about the channel statistics and network, but practices a reinforcement learning framework in order to qualify the nodes to familiarize their routing strategies, and optimally activities the statistical opportunities and receiver diversity. The proposed arrangement utilizes a reinforcement learning framework to resourcefully route the packets level in the lack of dependable acquaintance about channel statistics and network model. The suggested routing scheme equally reports the issues of learning and routing in an opportunistic background, where the network assembly is considered by the transmission achievement chances